PPARA and metabolic dysfunction-associated steatotic liver disease: PPARα regulates several aspects of lipid metabolism [19], and in keeping with this, it was demonstrated that OEA, by recruiting PPARα, reduces serum cholesterol and triacylglycerol (TAG) levels and has beneficial effects on the high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) in rats, by stimulating fatty acid β-oxidation, and by inhibiting lipogenesis [20].