LGALS3 and heart failure: To discern the complex differences of biomarkers, further studies are needed to investigate the use of a single biomarker (galectin-3 or sST2) versus combined biomarkers (galectin-3, sST2 and/or other markers) which has been done for adult with heart failure but not yet for ECLS patient [40,41,68], and sampling at single time point versus multiple time points in ECLS patients.