Several reports owing to WNK-SPAK/OSR1 kinases as the most involved signaling pathway in the regulation of neuronal Cl− and cell volume homeostasis do exist [60,65,70,71,123] and these established roles of the WNK-SPAK/OSR1-CCC pathway have alluded to their connection with stroke [19,65,71]. The gene discussed is OSR1; the disease is Stroke.