Scientific phenotypical/genotypical relationship of the TGFBI corneal dystrophies may only be possible in forthcoming prospective studies in which corneal presentation is thoroughly recorded in direct and indirect illumination and by pharmacologically dilated pupil and focusing the epithelium, the stroma and the endothelium, and the minimum of five patients in three generations in one family are explored. Here, TGFBI is linked to corneal dystrophy.