It has been shown that HTyr is able to affect cancer cell proliferation, mainly in hypotoxic conditions, modulating the transcription and translation of different proteins involved in peroxisome proliferator-activated receptor gamma coactivator 1-alpha/Nuclear factor erythroid 2-related factor 2 (PGC-1α/Nrf2) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha/Estrogen-related receptor α (PGC-1α/ERRα) pathways, responsible for cellular antioxidant response [98]. Here, NFE2L2 is linked to cancer.