In melanoma cells, OC suppressed proliferation, migration, invasion and induced apoptosis by downregulating Mcl-1, Bcl-xL, MMP-9, MMP-2 genes expression as well as the phosphorylation and activation of STAT3; it also suppressed the expression of JAK2 and Src kinases, inhibiting cell invasion and angiogenesis [79]. Here, STAT3 is linked to melanoma.