CRBN and Cerebral ischemia: CRBN also suppressed deleterious α-T172 phosphorylation in a rat model of cerebral ischemia (middle cerebral artery occlusion/reperfusion) in response to thalidomide, a known CRBN modulator, and attenuated cardioprotective AMPK activation in mouse hearts in response to ischemia/reperfusion [141,142].