Y-RNA hY4 was also found to be a highly abundant RNA species present in plasma exosomes from chronic leukocytic lymphoma (CLL) patients and that hY4 enriched exosomes skew normal monocytes towards CLL associated phenotypes due to the exosomal hY4 RNAs acting as a driver of TLR7 signaling [68]. Here, TLR7 is linked to B-cell chronic lymphocytic leukemia.