Y-RNA hY4 was also found to be a highly abundant RNA species present in plasma exosomes from chronic leukocytic lymphoma (CLL) patients and that hY4 enriched exosomes skew normal monocytes towards CLL associated phenotypes due to the exosomal hY4 RNAs acting as a driver of TLR7 signaling [68]. The gene discussed is RNY4; the disease is B-cell chronic lymphocytic leukemia.