INS and metabolic dysfunction-associated steatohepatitis: A recent Bayesian network meta-analysis of randomized controlled trials (RCTs) and non-randomized intervention studies of individuals with biopsy-proven NASH showed that pioglitazone and bariatric surgery are the two most effective treatment options for NASH, thereby supporting the notion that weight loss and improvement in hepatic insulin resistance are promising approaches for the treatment of this metabolic liver disease [19].