BRCA1 and breast carcinoma: Since mutations in TP53 tumor suppressor might lead to dramatic phenotypic changes and diversification of cell responses to stress, the authors analyzed the functional fingerprints of sporadic breast cancer-related p53 mutants, many of which are also associated with familial cancer proneness such as the Li–Fraumeni syndrome and germline BRCA1/2 mutant-associated cancers, and concluded that functional and non-functional missense mutations may affect the clinical behavior and outcome of breast cancer patients [85].