Wang et al. investigated germline variants in ATR/CHEK1 and ATM/CHEK2 (rs35514263 in ATR; rs492510, rs558351 in CHKE1; rs189037 in ATM; rs2236141, rs5762748, rs2236142, and rs9620817 in CHEK2) acting in DDR and their association with CRC risk in a Chinese population. Here, ATM is linked to colorectal carcinoma.