In mice, p53 downregulates genes that are essential for telomere metabolism (11 genes, including those encoding telomerase, helicase, and the Shelterin complex), DNA repair (such as Fancd2, a gene encoding a key protein of the Fanconi anemia DNA repair pathway which enables the completion of DNA replication by removing inter-strand crosslinks), and centromere structure. This evidence concerns the gene TP53 and Fanconi anemia.