For example, in male mice that underwent trans-aortic constriction to induce HF (pressure-overload model), 100 mg/kg/day of gallic acid or medications used in the treatment of HF, including 3 mg/kg/day of losartan (AT1R blocker), 1 mg/kg/day carvedilol (β-blocker), or 3 mg/kg/day furosemide (3 mg/kg/day), for two weeks following confirmed HF resulted in a reduction of cardiac collagen I and α-smooth muscle actin to a large extent with gallic acid treatment but minimally with medications [353]. The gene discussed is AGTR1; the disease is hydrops fetalis.