These factors in turns activate the production of cytokines (e.g., interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-23 (IL-23) and tumor necrosis factor-α (TNF-α)), chemokines and prostaglandins that recruit leukocytes, mainly myelomonocytic cells, and further activate the key transcription factors (NF-κB, STAT3 and HIF1α) in inflammatory, stromal and tumor cells [27,28,29,30,31,32]. The gene discussed is IL37; the disease is neoplasm.