TNF and neoplasm: In normal-weight people macrophages show an M2-like anti-inflammatory phenotype, while in obese people, they show an M1-like pro-inflammatory pattern that is able to produce tumor-promoting cytokines and chemokines, such as TNF, IL-6, IL-1β, CCL2 (C-C motif chemokine ligand 2) and MIF (macrophage migration inhibitory factor) [121,122].