Keratinocytes can also be stimulated to produce CXCL8, promoting the proliferation and migration of cSCC (cutaneous squamous cell carcinoma) cells, suggesting an important role of the CXCR1/CXCR2 (C-X-C motif chemokine receptor 1/2) axis in UV inflammation and tumorigenesis [83]. This evidence concerns the gene CXCR1 and cutaneous squamous cell carcinoma.