IL33 and cutaneous melanoma: Several studies showed that ΤΝF-α, IL-1β and IL-6 stimulate macrophage migration and fuel inflammation at the exposed site [77,78,79,80]; IL-8 promotes tumors and metastasis in primary cutaneous melanoma after UV irradiation, while IL-33 (interleukin-33), known to promote angiogenesis, can be stimulated by inflammatory UV-B radiation [81,82].