The major actors in the myeloid compartment are tumor-associated macrophages (TAM); these cells are characterized by M2-like features [34] and they are responsible for the secretion of signaling molecules, such as transforming growth factor beta (TGF-β), vascular endothelial growth factor (VEGF), macrophage colony-stimulating factor (M-CSF), interleukins or chemokines (interleukin-10 (IL-10), IL-6, and C-X-C motif chemokine 8 (CXCL-8)) [35,36,37] and extracellular vesicles (EVs) with immunosuppressive properties [38]. The gene discussed is CXCL8; the disease is neoplasm.