POU5F1 and infection: In agreement with published data on a decrease of octamer-binding transcription factor 4 (OCT4) expression after CVB3-EGFP infection as previously detected by Western blot analysis [23], we have marked in Figure 1B a red-colored area in SOM portraits indicative for down-regulation of signature genes of pluripotency (OCT4- and NANOG-targets taken from [27]).