Serious adverse events also included bleeding (n=4), bowel perforation (n=2), acute renal failure (n=2), acute neurotoxicity (n=2), pulmonary thromboembolism (n=1), atrial fibrillation (n=1), vomiting plus diarrhoea (n=1), ischaemic stroke (n=1), and increased alanine aminotransferase (n=1). This evidence concerns the gene GPT and atrial fibrillation.