INS and type 2 diabetes mellitus: Coherent with a pleiotropic role of ADCY5, variants in ADCY5 have further been associated with 2-h glucose challenge (Saxena et al., 2010), fasting glucose, T2D (Dupuis et al., 2010; Fuchsberger et al., 2016), and with beta cell insulin secretion (Dayeh et al., 2013).