CRX and Leber congenital amaurosis: In this article, Swaroop and colleagues show impaired expression of opsin visual pigments in retinal organoids derived from iPSC lines of patients with Leber congenital amaurosis, caused by dominant mutations in the photoreceptor transcription factor gene CRX. AAV-mediated CRX gene augmentation partially restores the expression of phototransduction genes, suggesting a potential therapeutic strategy.