Notably, most studies have reported dysregulated and/or inflammatory responses in patients with severe COVID-19, including decreases in regulatory T cells [8], increased neutrophil counts [5,6,8] and increases in pro-inflammatory cytokines such as IL-6 and TNF [6,8,9], thereby suggesting that a dysregulated state of inflammation is associated with severe COVID-19. The gene discussed is TNF; the disease is COVID-19.