MMP1 and neoplasm: Fig 7B, 7C and 7D show that the invasion patterns of MMP1s and integrins are maintained over time. The experimental results in Fig 7DE provide the distributions of GB membrane, active integrins, and MMP1 markers at the same time and show their co-localization in the TM region. The results also show a displacement of the MMP1 distribution with respect to active integrin and tumor membrane distributions. The model outcomes coincide with the experimental data in Fig 7DE.