The combination of the different fluxes and the proliferation term leads to the following equation governing glioma cell dynamics:∂N∂t=νN∂∂x(NmN2+(νNvN)2|∂N∂x|2∂N∂x)-∂∂x(Na11+(∂P∂x)2∂P∂x+Na21+(∂A∂x)2∂A∂x)+a3N(1-NKN)(4)Using this modeling approach, we demonstrate not only the role of proteases (in the specific, of the MMP1 family) and integrins in GB motility, but also their co-localization and spatial distribution with respect to the location of the tumor front. The gene discussed is MMP1; the disease is central nervous system cancer.