TP53 and neoplasm: Previous candidate gene studies in elephants have identified duplications of tumor suppressors such as TP53 and LIF, among others, suggesting that an increased copy number of tumor suppressors may contribute to the evolution of large body sizes in the elephant lineage (Abegglen et al., 2015; Sulak et al., 2016; Vazquez et al., 2018; Caulin et al., 2015; Doherty and de Magalhães, 2016).