This includes leukocyte chemotaxis in response to CCR2 trafficking (Laban et al, 2018), breast cancer cell invasion and metastasis in response to EGFR internalization (Philippar et al, 2008; Vehlow et al, 2013), ephrin/Eph‐mediated fibroblast repulsion via Eph receptor internalization (Evans et al, 2007) and potentially other situations, in which Ena/VASP proteins were implicated in attractive or repulsive guidance cue signaling (Wills et al, 1999; Bashaw et al, 2000; Klostermann et al, 2000; Lebrand et al, 2004; Toyofuku et al, 2004). This evidence concerns the gene EPHA1 and breast cancer.