In resting endothelial cells, ICAM‐1 membrane expression is very weak, but it increases dramatically in the case of endothelial injury, which is one of the major features of endothelial dysfunction occurring in numerous pathological states such as atherosclerosis, heart failure, hypertension, diabetes or septicemia (Deanfield et al., 2007; Kwan et al., 2007; Liao, 2013; Sena et al., 2013). This evidence concerns the gene ICAM1 and heart failure.