IGHE and asthma: Cockroach SPT reactivity was also inversely associated with total IgG4/total IgE ratios in the urban survey (0.41 [0.24, 0.70], p = .002) and in the asthma case‐control study (0.42 [0.25, 0.73], p = .002), and with cockroach‐specific IgG4/IgE ratios in the asthma case‐control study (0.42 [0.19, 0.94], p = .034) [Figure 2B].