IGHE and asthma: In all three studies, cockroach SPT reactivity was inversely associated with total IgE/cockroach‐specific IgE ratios (rural: 0.23 [0.16, 0.32], p < .001; urban: 0.31 [0.15, 0.64], p = .003; asthma study: 0.23 [0.17, 0.33], p < .001) [Figure 2B].