Several human studies have suggested that helminth‐induced IgG4 is important in protection against allergy: among school‐age children in rural Ecuador, Ascaris‐specific IgG4 was inversely associated with allergen skin prick test (SPT) reactivity2; in a Sm‐endemic Ugandan rural setting, we observed an inverse association between house dust mite–specific IgG4/IgE ratios and reported recent wheeze.17 The gene discussed is IGHE; the disease is allergic disease.