IGHE and asthma: In our case‐control study, “allergic” (SPT positive) asthma cases had lower HDM‐specific IgG4/IgE, total IgG4/total IgE and total IgE/allergen‐specific IgE ratios, compared with “non‐allergic” (SPT negative) asthma cases (Table S3 and Figure S1A and S1B).