Assessment of associations between antibody ratios and skin prick test reactivity, independently among asthma cases and non‐asthmatic controls, showed observations akin to the above: cockroach and HDM SPT reactivity were inversely associated with allergen‐specific IgG4/IgE ratios, total IgE/allergen‐specific IgE ratios and total IgG4/total IgE ratios (Table S3). The gene discussed is IGHE; the disease is asthma.