In diabetic SHR, Ang-(1-7) treatment improved renal function by inhibiting the Nox4/ROS system [146] and in a mouse model of cardiac hypertrophy AVE 0991, a nonpeptide Ang-(1-7) analogue, prevented left ventricular hypertrophy and improved heart function by down-regulating Nox2 and Nox4 and decreasing oxidative stress [147]. This evidence concerns the gene ANG and cardiac hypertrophy.