APC and attenuated familial adenomatous polyposis: MLPA analysis elucidated a decrease in the copy number of the promoter 1A and 1B region of the APC gene, which was different from previous reports in which the mutations in the APC gene associated with AFAP have mainly been presented in the 5′ upstream exons, in exon 9 and in the distal 3′ end [15, 18].