When hyperphosphorylated (PP-Tau), Tau monomers detach from microtubules and tend to irreversibly aggregate in oligomers at first and in neurofibrillary tangles at a later time, as it occurs in a group of neurodegenerative disorders named tauopathies, such as Alzheimer’s disease (AD) or Parkinson disease (PD) (Gerson et al. 2016; Kovacs 2017). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.