IL6 and temporal arteritis: This finding challenges preconceptions that fatigue and depression, which are characterized by elevation in IL-6 [17], are an inevitable part of systemic inflammatory diseases such as GCA and TAK; monitoring health-related quality of life may be an efficient way of assessing how well the underlying inflammatory disease is being controlled by treatment, particularly since measurement of acute phase markers in TCZ-treated patients tends to be clinically uninformative.