Most of the cancers that present an overexpression of PHGDH harbour TP53 mutations, including colorectal cancer (55%-60% TP53 mutation), intestinal gastric cancer (66% TP53 mutation), melanoma (85% TP53 mutation), and non-small cell lung cancer (50% TP53 mutation)[46-49]. The gene discussed is TP53; the disease is melanoma.