PHGDH has been demonstrated to be upregulated in a wide variety of biologically distinct cancers, including colorectal cancer[33], gastric cancer[34], breast cancer[35,36], melanoma[37], Ewing’s sarcoma[38], cervical cancer[39], pancreatic cancer[40], thyroid cancer[41], colon cancer[42], lung adenocarcinoma[43], and non-small cell lung cancer[44]. This evidence concerns the gene PHGDH and colorectal cancer.