First, the discovery of genes such as KLK3 and AR altered in germline, somatic (tumour), epigenome, and the transcriptome, coupled with the findings that aberrant DNA methylation affects gene expression demonstrates that integrative analysis combining information from complimentary technologies provides a unified approach for the discovery of potential clinically actionable biomarkers in aggressive PCa. The gene discussed is KLK3; the disease is posterior cortical atrophy.