Interestingly, the 41 gene signature included the genes BRCA1, KLK3, KLK2, PDLIM5, and ITGA6, containing genetic variants reported to be directly associated with aggressive PCa [4, 46–48], and the genes AMIGO2, ATF71P, BRCA1, KLK2, KLK3, MDM4, and PDLIM5 used in gene panels for PCa screening and assessing disease prognosis [46–48]. Here, KLK2 is linked to posterior cortical atrophy.