In addition, the channel subtype KV1.3 has been found in the plasma membrane of human melanoma cells (Artym and Petty, 2002), and 4-ampy can block KV in T-leukemic Jurkat cells, decreasing cell growth and proliferation by accumulating cyclin-dependent kinase inhibitor p27kip1 with low effects on apoptotic mechanisms (Renaudo et al., 2004). This evidence concerns the gene CDKN1B and melanoma.