Physiologically, hypoxia in the early embryonic stage is crucial in stem cell functions, pluripotency, and organ development (Simon and Keith, 2008; Fathollahipour et al., 2018; Kuo et al., 2018) Pathologically, Eliasz et al. demonstrated that hypoxia-activated Notch 1 can increase IGF-1R expression by binding to the IGF-1R promoter, thereby enhancing IGF-1R-mediated antiapoptosis in lung adenocarcinoma (Eliasz et al., 2010). Here, IGF1R is linked to lung adenocarcinoma.