Genetic ablation of the Drp1 gene is embryonically lethal at day E12.5 (Manczak et al., 2012), however cardiac-specific deletion of Drp1 in the murine adult heart triggers mitochondrial elongation and mitophagy suppression leading to a higher susceptibility to ischemia/reperfusion and cardiomyopathy (Ikeda et al., 2015). Here, DNM1L is linked to cardiomyopathy.