Ineffective epithelial–mesenchymal transition (EMT) and metastasis suppression were observed in MDA-MB-231 and MCF-7 cell lines treated with transforming growth factor-β (TGF-β) in which STIM1 was knocked-down, proving a clue of the role of SOCE in TGF-β-induced cancer progression (Zhang et al., 2017). The gene discussed is TGFB1; the disease is cancer.