Other recently described proteins that maintain MAM integrity are DJ-1 (oncoprotein encoded in PARK7 gene) (Xu et al., 2018; Liu Y. et al., 2019; Basso et al., 2020) and PDZ domain-containing protein 8 (a synaptotagmin-like mitochondrial lipid-binding protein domain-containing ER transmembrane protein) that has been implicated in ER-dependent mitochondrial calcium homeostasis (Hirabayashi et al., 2017; Elbaz-Alon et al., 2020), while pannexin 2 has been reported to sensitize cancer cells to apoptotic stimuli (Le Vasseur et al., 2019). Here, PARK7 is linked to cancer.