In turn, silencing of Orai1 and 2 with SOCE chemical inhibitors and siRNAs inhibits calcium uptake and suppresses cancer cell proliferation, colony formation, and migration in association with inhibition of the Akt/mammalian target of rapamycin (mTOR)/nuclear factor κB (NF-κB) pathway (Singh et al., 2020). Here, ORAI1 is linked to cancer.