Overexpression of both mitofusins in cancer cells has been demonstrated, as well as their interactions with phosphatidylinositol 3-kinase (PI3K)/Akt and P21Ras pathways, which are involved in cell proliferation, metastasis, and invasion processes (Ma et al., 2015; Li et al., 2018; Moghaddam et al., 2020). Here, AKT1 is linked to cancer.