Migration is also associated with cell morphology, i.e., when IP3R3 is silenced, a rounded shape is produced in highly invasive cancer cell lines, resulting in a low rate of adhesion and migration, as a consequence of Ca2+ oscillation and cytoskeletal changes driven through the ARHGAP18/RhoA/mDia1/FAK signaling pathway (Vautrin-Glabik et al., 2018). Here, ITPR3 is linked to cancer.