AKT1 and cancer: Accumulating evidences suggest that leptin induces EMT in cancer cells via different molecular pathways including JAK/STAT pathway, β-catenin activation via Akt/GSK3 and MTA/Wnt1 pathway, and activation of IL-8 via PI3K/Akt dependent pathway (Yan et al., 2012; Wang L. et al., 2015; Mullen and Gonzalez-Perez, 2016).