KLF4 and colorectal cancer: For example, Zeng et al. (2018) showed that in colorectal cancer, exosomal miR-25-3p is transferred from colorectal cancer cells to endothelial cells, where it regulates the expression of VEGFR2, ZO-1, occludin, and claudin5 by targeting KLF2 and KLF4, thus increasing vascular permeability and promoting angiogenesis.