The Thy-1-β3 Integrin interaction induces cell migration through a Ca2+/P2X7R signaling axis in astrocytes (Alvarez et al., 2016; Lagos-Cabré et al., 2017) and in MDA-MB-231 breast cancer cells (the present study), but whether melanoma metastasis was also dependent on Thy-1-β3 Integrin binding was unknown. This evidence concerns the gene THY1 and breast cancer.