THY1 and melanoma: Most importantly, silencing of β3 Integrin in melanoma cells (this paper) or injection of wild type B16F10 cells in Thy-1 knock-out mice (Schubert et al., 2013) abolish melanoma lung metastasis in vivo, indicating that disruption of the Thy-1-αVβ3 Integrin interaction precludes melanoma metastases.