Altogether, these results indicate that β3 Integrin is necessary for Thy-1-induced melanoma cell migration and invasion and that the molecular mechanisms triggered downstream of the Thy-1-β3 Integrin interaction include the Ca2+/P2X7R signaling axis that we previously described in astrocytes (Alvarez et al., 2016; Lagos-Cabré et al., 2017) and now show here for breast cancer cells. This evidence concerns the gene THY1 and breast cancer.