FTO and melanoma: The FTO negatively regulates the response to anti-programmed death 1, an immunotherapeutic agent, through the action of melanoma-intrinsic genes including PD-1, C-X-CR-4, and SOX10; those are the major potential gene targets for demethylation by FTO (Yang S. et al., 2019; Melstrom and Chen, 2020; Zhao et al., 2020).