The ALKBH5-dependent demethylation of FOXM1 and NANOG transcripts (main regulators of cancer stem cells) promotes chemoresistance of platinum-based drugs through negative regulation of human DEAD-box RNA helicase (DDX3), which are primarily involved in the innate immunity, multiple cell signal processes, and numerous aspects of RNA metabolism (Shriwas et al., 2020). This evidence concerns the gene ALKBH5 and cancer.