NANOG and cancer: The ALKBH5-dependent demethylation of FOXM1 and NANOG transcripts (main regulators of cancer stem cells) promotes chemoresistance of platinum-based drugs through negative regulation of human DEAD-box RNA helicase (DDX3), which are primarily involved in the innate immunity, multiple cell signal processes, and numerous aspects of RNA metabolism (Shriwas et al., 2020).