The role of such function in detoxication of aldehydes (Bunik and Fernie, 2009) may underlie association of the dysregulated DHTKD1 expression with diabetes, obesity and cancer (Lim et al., 2014; Wu et al., 2014; Kiełbus et al., 2015; Plubell et al., 2018; Timmons et al., 2018). The gene discussed is DHTKD1; the disease is obesity due to melanocortin 4 receptor deficiency.