The DHTKD1 expression is known to be changed in the age- and metabolic-syndrome-related pathologies, such as obesity, diabetes, neurodegenerations, and inflammatory disorders (Xu et al., 2012, 2018, 2019; Lim et al., 2014; Wu et al., 2014; Kiełbus et al., 2015; Plubell et al., 2018; Sherrill et al., 2018; Timmons et al., 2018; Luan et al., 2020). Here, DHTKD1 is linked to obesity due to melanocortin 4 receptor deficiency.