FGFR1 is a receptor tyrosine kinase that plays a crucial role in a variety of biological processes in tumor cells, including survival, proliferation, apoptosis, and differentiation.[36] FGFR1 signaling has a close relationship with EMT‐associated resistance of 1st and 2nd EGFR‐TKIs.[18b,c] Recently, focal FGFR1 amplification was observed in the AZD9291‐resistant tumor from one EGFR‐T790Mmutant NSCLC patient.[37] Our data indicated that FGFR1 overexpression might also contribute to AZD9291 resistance. The gene discussed is NTRK1; the disease is neoplasm.