MAPK3 and non-small cell lung carcinoma: In this study, CP@NP‐cRGD showed a significant inhibitory effect of ERK1/2 phosphorylation in the AZD9291‐resistant NSCLC cell line, while there was no significant difference in t‐ERK1/2 level, suggesting the involvement of the ERK1/2 pathway of AZD9292‐resistance, which need further study.