ORF64USP was found to process K48‐ and K63‐linked polyubiquitin chains in vitro, and to target and deubiquitinate RIG‐I, thus leading to an inhibition of IFN‐I signaling.[252, 254] HBx, encoded by hepatitis B virus, another DNA virus, deubiquitinates both RIG‐I and TRAF3 for K63‐linked ubiquitin chains and inhibits the production of type I interferon.[255, 256] Epstein‐Barr virus (EBV) is a human oncogenic herpesvirus that presents a prolonged latent infection in the host. This evidence concerns the gene RIGI and disease arising from reactivation of latent virus.