As the first DUB identified to deubiquitinate RIG‐I, Cylindromatosis (CYLD) removes its K63‐linked polyubiquitin chains, preventing any basal activation levels and thus dampening IFN production triggered by RIG‐I.[162] Upon viral infection, or in the presence of a tumor necrosis factor, the CYLD expression level is downregulated to enhance IFN production. Here, IFNA1 is linked to viral infectious disease.