As the first DUB identified to deubiquitinate RIG‐I, Cylindromatosis (CYLD) removes its K63‐linked polyubiquitin chains, preventing any basal activation levels and thus dampening IFN production triggered by RIG‐I.[162] Upon viral infection, or in the presence of a tumor necrosis factor, the CYLD expression level is downregulated to enhance IFN production. The gene discussed is RIGI; the disease is viral infectious disease.