To determine if the RAP‐RAGE interaction would work in AD patients, we directly incubated RAP‐RL with brain slices from AD patients, finding that RAP‐RL exhibited higher accumulation along the vessel walls than that in the parenchyma, other than extensively distributed in various cells in the non‐AD brain samples without specific accumulation along the vasculature (Figure S3, Supporting Information). This evidence concerns the gene LRPAP1 and Alzheimer disease.