Consistent with that found in the brain of AD patients, those APP/PS1 mice showed aberrant vascular network with the capillary diameter (4.43 ± 0.16 μm) and capillary density (3.84 ± 0.29%) in the cortex significantly lower than those in the age‐matched WT mice (5.27 ± 0.16 μm and 5.92 ± 0.42%, respectively) (Figure 5a–c). The gene discussed is APP; the disease is Alzheimer disease.