Moreover, as inflammatory factors including IL‐1, IL‐6, GM‐CSF, IL‐12 and IL‐23, and TNF‐α were all upregulated under AD condition.[23] RAP‐RL, which alleviates neuroinflammation (Figure S10, Supporting Information) might also protect the noninjured cerebral microvessels from the neuroinflammatory injury. This evidence concerns the gene CSF2 and Alzheimer disease.