Furthermore, the PB1 domain of p62 mediates homopolymerization of p62 and facilitates its interaction with the cargo.[22] There are a series of cargo receptors that act as a bridge between the ubiquitinated proteins or organelles and gamma‐aminobutyric acid receptor‐associated protein (LC3/GABARAP) family members in the core autophagy machinery.[23] The dysfunction of selective autophagy is related to the development of cancer, aging and other diseases.[24, 25, 26, 27]. Here, SQSTM1 is linked to cancer.