This eventually brought us to the conclusion that TP53 is the protein with the highest degree, TSPO is the protein with largest BC, and EGFR is the protein with highest CC values, but TP53 obtained the important position in the network due to its degree, BC, and CC values, indicating that TP53 is centrally localized in the network and is a significant bottleneck protein in oral cancer protein-protein interaction network. Here, EGFR is linked to lip and oral cavity carcinoma.