In a GWAS by Mells et al an association between PLCL2 rs1372072 polymorphism and risk of Primary biliary cirrhosis was found.15 In the other study, Sawcer et al investigated the cell-mediated immune mechanism in multiple sclerosis and reported an increased risk of disease in carriers of PLCL2 rs9821630A>G polymorphism.16 An increase in the risk of rheumatoid arthritis was shown for PLCL2 rs4535211 polymorphism.17 In recent studies, Arismendi et al and Tsoi et al found an association between PLCL2rs1372072 and systemic sclerosis,18 and PLCL2rs4685408 and Psoriasis19 respectively. This evidence concerns the gene PLCL2 and multiple sclerosis.