Other genes were involved at cancer formation and development, for example AK4 was found to be involved in the esophageal cancer [62], RSG6 was found to be associated to bladder cancer [7], SLC43A2 was found to be involved in metastatic gastric cancer [61] and RPH3AL was found to be associated to colorectal adenocarcinoma [23]. Here, AK4 is linked to esophageal cancer.