NFE2L2 and chronic kidney disease: Therefore, the aim of this study conducted in mice was twofold: (1) to assess the effects of adenine (0.2% w/w in feed for 4 weeks)-induced CKD on SBP, heart histology, inflammation, oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) expression, and DNA damage and (2) to evaluate the impact of the adenine-induced CKD on circulating platelets, photochemically induced thrombosis in pial microvessels in vivo and prothrombin time (PT), and activated partial thromboplastin time (aPTT) in vitro.