Therefore, the aim of this study conducted in mice was twofold: (1) to assess the effects of adenine (0.2% w/w in feed for 4 weeks)-induced CKD on SBP, heart histology, inflammation, oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) expression, and DNA damage and (2) to evaluate the impact of the adenine-induced CKD on circulating platelets, photochemically induced thrombosis in pial microvessels in vivo and prothrombin time (PT), and activated partial thromboplastin time (aPTT) in vitro. This evidence concerns the gene F2 and chronic kidney disease.