Further studies on STZ- and alloxan- (ALX-) induced DM mice models have revealed that such compounds increase the activation of IRS-1/PI3K/Akt pathway, leading to translocation of GLUT4 and suppression of GSK-3β, thereby stimulating glucose uptake by skeletal muscle [29] and other tissues, increasing liver glycogen content at the same time [39]. Here, SLC2A4 is linked to diabetes mellitus.