In ALX-induced DM mice model, saponins from MC have a significant effect on activating AMPK, which promotes glycogen synthesis [43] via glycogen synthase [44]; cucurbitane triterpenoids can improve cellular uptake of glucose via upregulating the transcription levels of AMPK-α1 and GLUT4 [39]. The gene discussed is SLC2A4; the disease is diabetes mellitus.