Adelaiye-Ogala et al. (2017) reported that EZH2 expression was linked to sunitinib resistance in RCC through an adaptive kinome reprograming, such as increased global tyrosine and serine phosphorylation as well as increased phosphorylated FAK. SOX5, one of SOX family involving in the regulation of tumor progression, is thought to contribute to EMT in different types of cancer (Grimm et al., 2019). Liu et al. (2019) reported lncRNA-GAS5 was responsible to sorafenib resistance by functioning as ceRNA to repress miR-21, which controlled its downstream target SOX5. Here, EZH2 is linked to renal cell carcinoma.