Furthermore, live cell imaging studies assessing degradation kinetics of APOBEC3G and PPP2R5A in the same cell established that the half-life of PPP2R5A is only ∼2 h slower than that of APOBEC3G following infection, which is striking given that APOBEC3G degradation is essential for HIV-1 infectivity and pathogenesis (Salamango et al., 2020). Here, PPP2R5A is linked to infection.