There are several major findings: first, brain lesions of patients with anti-LGI1 encephalitis were mainly located in MTL and BG as has been previously described (15, 18, 20–22); second, MTL lesions were more likely to be observed in patients with memory impairment, whereas BG lesions were more commonly observed in patients with FBDS; third, the extent of signal abnormalities in the lesion area was correlated with disease severity, as measured by mRS scores. This evidence concerns the gene LGI1 and memory impairment.