TSPAN5 and major depressive disorder: Taken together, these results raise the possibility that TSPAN5 SNPs might be biomarkers for acamprosate treatment response, and that the gene itself might play a role in cross-talk between MDD and AUD, two psychiatric disorders with high co-morbidity and, perhaps, partially shared pathophysiology (Kendler et al., 1993; Walters et al., 2018; Gelernter et al., 2019).