Furthermore, when we describe the development of a machine learning-based, multiply replicated predictive algorithm for SSRI response in MDD, it was found that SNPs from all four of the signals identified during these two GWAS, those for TSPAN5, ERICH3, DEFB1 and AHR, all contributed to the predictive accuracy of the algorithm (Athreya et al., 2018; Athreya et al., 2019b). This evidence concerns the gene DEFB1 and major depressive disorder.