CRP and obesity due to melanocortin 4 receptor deficiency: Also, hypertension, insulin resistance, diabetes mellitus, hypercholesterolemia, obesity, dyslipidemia, a high level of C-reactive protein (CRP), immunological disorder, vascular wall inflammation, a genetic predisposition, bacterial infection, stress, alcohol consumption, and smoking were all observed to be risk factors for atherosclerosis development (Holvoet, 2012).